Mezvinsky has quit his job as an investment banker in favour of a three-month break at the exclusive ski resort of Jackson Hole in Wyoming, reports the Daily Mail.
But rather than accompanying her husband on the extended break, the Secretary of State's daughter will be remaining in New York.
The nature of the couple's temporary separation remains something of a mystery.
The paper reported that Mezvinsky had left his job in order to spend a season skiing at Jackson Hole, which is a favourite with celebrities such as Clint Eastwood and David Beckham.
Clinton, meanwhile, is remaining in New York, where she is currently studying for a degree in public policy at the city's Columbia University.
The fact that the pair will be living apart comes as something of a surprise, given that friends claim Clinton is desperate to start a family.
A source close to the couple said that the 30-year-old would be visiting her husband every few weeks. (ANI)