Jolie will portray the role of medical examiner Dr. Kay Scarpetta, reports Variety.
There are 16 Scarpetta novels, however, the new film won't be made on a specific Cornwell mystery novel.
The opera-loving coroner Scarpetta will be the lead in a suspense thriller in the vein of "The Silence of the Lambs" and "Seven."
Cornwell also made a deal last year with Lifetime Television to adapt two non-Scarpetta novels, "At Risk" and "The Front." (ANI)