The Indian combination were to blame themselves for the loss as they committed as many as 19 unforced errors to eight by their opponents in the whole game. They also sent down seven double faults to their opponents' mere two.
Sania and Bhupathi were particularly erratic in the first set presenting to their opponents 13 unforced errors and three service double faults.
Their defeat after one hour and 16 minute contest means both of them did not have much to show from the prestigious Grand Slam event.
Bhupathi did not compete in the men's doubles while Sania had lost her doubles, partnering Israeli Sahar Peer, in pre-quarter finals and singles in the second round.
Meanwhile, unseeded Indian Rupesh Roy lost to eighth seed Kellen Damico of USA 3-6, 6-3, 6-10 in the boys' singles second round.
Roy had earlier beaten Sean Thornley of England 5-7, 7-6(4), 10-7 in the opening round.