Among those who surrenedered include three leading commanders of rebel tribal chief Nawab Akbar Khan Bugti.
According to local officials, the militants also surrendered a huge cache of arms and ammunition, which they allegedly used in the ongoing insurgency in the restive province.
Balochistan's Home Minister Shoaib Nausherwani described the laying of arms by militants as a good omen.
The latest surrender came days after some 45 militants killed in different parts of Balochistan especially near Dera Bugti, the stronghold of Nawab Akbar Bugti, in different military operations.
The fresh wave of violence in the southwestern Balochistan province erupted last December following the federal government's unveiled plans to explore fresh oil and gas reserves in Kohlu district.
Baloch nationalists accuse the Pakistani government of not passing on the benefits of economic development and share of provincial natural resources to their people.
The government blames the local tribal chiefs including Bugti of deteriorating law and order in the province.
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